Although earthquakes are not predictable at the moment, with the aid of accurate seismic wave propagation analysis, we could simulate the potential hazards at all distances from possible fault sources by understanding the seismic wave velocity structure of the earth and the rupture process during large earthquakes. The software package SPECFEM3D_GLOBE simulate three-dimensional global and regional seismic wave propagation based upon the spectral-element method (SEM). The main developers are Dirmitri Komatitsch, Jeroen Tromp, and Qinya Liu. We ported and dissemnated this application on the EUAsiaGrid infrastructure. Objective of the earthquake disaster mitigation in EUAsiaGrid is to demonstrate the value of new research paradigm on risk reduction by taking advantage of global e-Science infrastructure. The fundamental perspective is to support earthquake research and innovation, and to facilitate the understanding of the earth by Grid. Based on the rational of seismological hazards mitigation, the three foremost tasks are: Sensor network for ground motion detection, Seismic data center to collect and archive all related earthquake data including basic geological data, and the seismic wave propagation analysis. Once the earthquake impact could be estimated, effective preparedness and disaster alleviation could be implemented accordingly. By taking into account of the topographical characteristics, accurate simulation would be possible for detailed risk estimation, then it will become crucial references for the disaster mitigation. Detailed historical seismic data is also important to understand the facts of ground motion, co-relations of events, and topographical changes over time in order to support the earth science researches.